Spatiotemporal Decouplingof Carbon and Energy FluxEnables Efficient Biomanufacturing of Aviation Fuel Precursors fromCO<sub>2</sub>
CO2からの航空燃料前駆体の効率的なバイオ製造を可能にする炭素とエネルギーフラックスの時空間的デカップリング (AI 翻訳)
Yang Ye, Feng Dong (142012), 边祥海, Dazhi Bai, Wenhui Wu, Xiaojing Jiang, Bin Yang (103252), Yang Hou (378690), Lecheng Lei (1645309), Jiazhang Lian, Zhongjian Li (1645306)
🤖 gxceed AI 要約
日本語
本研究は、二酸化炭素(CO2)から航空燃料前駆体であるエピイソジザエンを高効率に合成する新規光バイオハイブリッドシステムを開発した。鉄単原子触媒を担持した窒素ドープカーボンドット(Fe-NC QDs)を用いて、細胞外でCO2をメタノールに変換し、細胞内でNADHを光触媒的に再生することで、炭素効率を大幅に向上させた。従来のメタノール供給法と比較して3倍の生産量を達成し、太陽光駆動型の循環型バイオエコノミーに貢献する。
English
This study developed a novel photobiohybrid system that efficiently synthesizes the aviation fuel precursor epi-isozizaene from CO2. Using a bifunctional catalyst of iron single atoms on nitrogen-doped carbon quantum dots (Fe-NC QDs), CO2 is reduced extracellularly to methanol while intracellularly regenerating NADH photocatalytically, achieving a 3-fold increase in product titer over conventional methanol-feeding. This spatiotemporal decoupling strategy advances solar-driven biosynthesis and circular bioeconomy.
Unofficial AI-generated summary based on the public title and abstract. Not an official translation.
📝 gxceed 編集解説 — Why this matters
日本のGX文脈において
日本はカーボンニュートラル目標達成のため、CO2資源化技術に注力しており、特に航空分野でのバイオ燃料開発は重要課題である。本成果は、CO2からの直接的な航空燃料前駆体合成を実証し、日本のカーボンリサイクル政策やSAF（持続可能な航空燃料）普及目標に貢献する可能性がある。
In the global GX context
Globally, this work addresses the critical challenge of carbon capture and utilization (CCU) for sustainable aviation fuels, a key sector for decarbonization. By decoupling carbon supply and energy regeneration, it offers a generalizable framework for solar-driven biosynthesis, relevant to global circular economy and climate goals under the Paris Agreement.
👥 読者別の含意
🔬研究者:Researchers in synthetic biology and CCU should note the spatiotemporal decoupling strategy that overcomes the carbon-efficiency bottleneck in photobiohybrid systems.
🏢実務担当者:Biofuel companies can explore this approach for scalable production of aviation fuel precursors from CO2, though further development is needed.
🏛政策担当者:Policymakers supporting carbon recycling and sustainable aviation fuel should consider funding advanced CCU technologies like this.
📄 Abstract（原文）
Sustainable biomanufacturing of high-value, structurally complex chemicals directly from CO<sub>2</sub> represents a frontier for carbon neutrality yet remains fundamentally constrained by a trade-off intrinsic to photobiohybrid systems: catabolic oxidation of fixed carbon must be invoked to regenerate intracellular reducing power, creating a futile cycle that reoxidizes photosynthetically fixed carbon back to CO<sub>2</sub> and erodes the overall carbon atom economy. Overcoming this bottleneck requires a unified platform capable of simultaneously supplying carbon substrates and regenerating reducing equivalents to maximize anabolic flux. Here, we report a spatiotemporally decoupled photobiohybrid system that achieves carbon-efficient CO<sub>2</sub> conversion through an “extracellular fixation and intracellular empowerment” strategy. A bifunctional catalyst of iron single atoms anchored on nitrogen-doped carbon quantum dots (Fe-NC QDs), featuring atomically dispersed Fe–N<sub>4</sub> active sites, was developed. Extracellularly, the Fe-NC QDs catalyze CO<sub>2</sub> reduction to methanol with a production rate of 826.10 μmol·g<sup>–1</sup>·h<sup>–1</sup> and 91.33% selectivity; intracellularly, the same QDs are internalized by engineered Pichia pastoris and photocatalytically regenerate NADH through a flavin-mediated electron transport chain. Coupling this bifunctional catalyst with an artificial phosphoketolase pathway enables the direct conversion of CO<sub>2</sub> into the C15 aviation fuel precursor epi-isozizaene at a titer of 1.98 mg·L<sup>–1</sup>, corresponding to a 3-fold increase in product titer over conventional methanol-feeding strategies. By spatiotemporally decoupling carbon supply from energy regeneration, this work establishes a generalizable framework for solar-driven biosynthesis of complex multicarbon feedstocks and advances the development of a circular bioeconomy.
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