Engineering Carbonic Anhydrase for Enhanced CO2 Capture and Valorization: A Review
強化されたCO2回収と価値化のための炭酸脱水酵素の工学：レビュー (AI 翻訳)
Xin Chen, Xiaofeng Ling, Xu Zhen, Yuanfen Xia
🤖 gxceed AI 要約
日本語
本レビューは、二酸化炭素回収・利用（CCUS）における炭酸脱水酵素（CA）の改変技術を総括。タンパク質工学や固定化技術により熱安定性や再利用性が向上し、機械学習との統合が新たな戦略として注目される。さらに、CAを介した高価値化学品やバイオエネルギーへの変換経路を概説し、産業規模でのカーボンニュートラル実現に向けた課題と展望を示す。
English
This review summarizes recent advances in engineering carbonic anhydrase (CA) for CO2 capture and utilization. Protein engineering and immobilization enhance thermal stability and reusability, with machine learning emerging as a transformative tool. CA-driven conversion to high-value chemicals and bioenergy is outlined, along with future prospects for scaling up industrial carbon neutrality pathways.
Unofficial AI-generated summary based on the public title and abstract. Not an official translation.
📝 gxceed 編集解説 — Why this matters
日本のGX文脈において
日本は2050年カーボンニュートラル目標達成のためCCUS技術の開発を推進している。本レビューはバイオ触媒によるCO2回収・利用の可能性を示し、日本の産業界における実用化研究の基盤となり得る。SSBJの非財務情報開示においても、CCUSは重要な要素であり、本技術の進展は開示内容にも影響を与える可能性がある。
In the global GX context
Globally, CCUS is a critical pillar for decarbonization, and this review highlights biological approaches that offer selectivity and mild operating conditions. The integration of machine learning with protein engineering represents a state-of-the-art strategy for developing robust enzymes. This paper provides a timely overview for researchers and industry stakeholders advancing carbon management solutions.
👥 読者別の含意
🔬研究者:The review consolidates protein engineering strategies and AI integration for CA, providing a comprehensive resource for researchers developing biocatalytic carbon capture.
🏛政策担当者:The paper highlights the potential of engineered microorganisms for CO2 utilization, which could inform R&D funding priorities in carbon management.
📄 Abstract（原文）
The continuous increase in atmospheric CO2 concentration exacerbates global climate change, making carbon reduction an urgent global priority. Carbonic anhydrase (CA), a highly efficient biocatalyst that converts CO2 into bicarbonate, demonstrates significant potential for carbon capture and resource utilization. However, the stability and catalytic efficiency of native CA in industrial environments are limited, particularly its poor thermal tolerance under flue gas conditions and its sensitivity to impurities, hindering its direct large-scale application. This review systematically summarizes recent advances in modifying microbial CA through protein engineering (e.g., directed evolution, rational design) and immobilization techniques, which have markedly enhanced its thermal stability, adaptability, and reusability. Among these, the integration of machine learning with high-throughput experimentation has emerged as a transformative strategy for CA engineering. Furthermore, we outline CA-driven pathways for CO2 conversion into high-value chemicals and bioenergy. Finally, future prospects are discussed, including interdisciplinary integration, computational modeling coupled with experimental validation, and comprehensive life-cycle and techno-economic assessments, to facilitate the scaled application of engineered microbial CA in carbon neutrality pathways. Collectively, this review highlights the critical role of engineered CA in bridging biocatalysis with industrial carbon management, offering a viable and sustainable pathway toward carbon neutrality.
🔗 Provenance — このレコードを発見したソース
- openalex https://doi.org/10.3390/cleantechnol8030063first seen 2026-05-17 06:28:50 · last seen 2026-05-20 05:13:01
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