Non-covalent interactions between lignin and cellulase: From molecular mechanisms to precision regulation.
Chengcheng Ye, Yuchen Han, Yanyi Tao, Ling'en Lv, Yu Long, Jianfeng Wu, Yongcan Jin, Wenjuan Wu
🤖 gxceed AI 要約
日本語
本レビューは、リグニンとセルラーゼ間の非共有結合相互作用の種類と機構を体系化し、酵素加水分解効率に及ぼす影響を分析。リグニン構造特性やセルラーゼ性質の影響を評価し、非生産的吸着を低減する戦略を検討。バイオマス変換の効率化に貢献。
English
This review systematically elucidates types and mechanisms of non-covalent interactions between lignin and cellulase, impacting enzymatic hydrolysis efficiency. It analyzes effects of lignin structural characteristics and cellulase properties, evaluates mitigation strategies for non-productive adsorption, contributing to efficient biomass conversion.
Unofficial AI-generated summary based on the public title and abstract. Not an official translation.
📝 gxceed 編集解説 — Why this matters
日本のGX文脈において
日本のバイオマスエネルギー政策（例：バイオマス発電、エタノール製造）に関連。リグニンによる酵素吸着阻害の克服は、国内の木質バイオマス利用促進に重要。ただし、直接的なGX開示や企業実務への影響は限定的。
In the global GX context
This paper is relevant to global bioenergy and biochemical production from lignocellulosic biomass. It addresses a key technical barrier in enzymatic hydrolysis, which has implications for renewable energy and materials. However, it does not directly address climate disclosure or financial topics.
👥 読者別の含意
🔬研究者:Provides mechanistic insights into lignin-cellulase interactions and strategies to improve enzymatic hydrolysis efficiency.
🏢実務担当者:Useful for biofuel and biochemical industries seeking to reduce enzyme costs and improve saccharification yields.
🏛政策担当者:Not applicable.
📄 Abstract（原文）
Lignocellulosic biomass is the most abundant renewable carbon source; its efficient utilization helps reduce dependence on fossil raw materials and promotes sustainable economic and social development. However, the sugar platform technology based on enzymatic hydrolysis and conversion of lignocellulose still faces major challenges. Among them, the non-productive adsorption of cellulase by lignin seriously restricts the efficiency and economics of the enzymatic hydrolysis process. Studies have shown that the presence of lignin can reduce cellulase hydrolysis efficiency by 30 %-80 %, and enzyme loading must be increased by 2-5 fold to achieve the same saccharification yield, significantly raising production costs. How to overcome the recalcitrance of lignin to enzymatic hydrolysis is an important topic in the industrial utilization of lignocellulosic biomass. Non-productive adsorption mainly relies on short-range non-covalent interactions such as hydrophobic interactions, hydrogen bonding, and electrostatic interactions. These interactions directly promote the ineffective binding of enzymes to the lignin surface. Recent studies have further revealed that long-range Van der Waals forces, electric double-layer interactions, and long-range hydrophobic interactions play an important promoting role in the initial approach stage between enzymes and lignin. Together, they constitute a long-range capture - short-range locking multi-step adsorption model, further exacerbating the intensity and persistence of non-productive adsorption. This review systematically elucidates the types and mechanisms of lignin-cellulase non-covalent interactions, analyzes the impacts of lignin structural characteristics (unit composition, functional groups, molecular weight) and cellulase properties (domain functions, surface hydrophobicity/charge), and evaluates current mitigation strategies.
🔗 Provenance — このレコードを発見したソース
- semanticscholar https://doi.org/10.1016/j.biortech.2026.135294first seen 2026-07-10 05:43:45
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