High-throughput analysis of target furocoumarins in Citrus essential oils by supercritical fluid chromatography with bio-based solvents
バイオベース溶媒を用いた超臨界流体クロマトグラフィーによる柑橘精油中のフロクマリン類のハイスループット分析 (AI 翻訳)
Cristian Reale, Giovanna Cafeo, Antonella Satira, Marina Russo, Paola Donato, Patrik Appelblad, Luigi Mondello
🤖 gxceed AI 要約
日本語
本研究は、柑橘精油中の光毒性ヘテロ環化合物を迅速分析するため、超臨界流体クロマトグラフィー（SFC）とバイオベースメタノールを用いた環境調和型メソッドを開発。分析時間3.5分、溶媒使用量840µL/run、1時間に17サンプルの高スループットを達成し、従来の液体クロマトグラフィーと比べ環境負荷を大幅に低減。
English
This work developed a green supercritical fluid chromatography (SFC) method using bio-based methanol for rapid analysis of phototoxic heterocyclic compounds in citrus essential oils. Achieved 3.5 min analysis time, 840 µL solvent per run, and 17 samples per hour throughput, substantially reducing environmental impact compared to conventional liquid chromatography.
Unofficial AI-generated summary based on the public title and abstract. Not an official translation.
📝 gxceed 編集解説 — Why this matters
日本のGX文脈において
日本の香料・化粧品業界では、製品の安全性と環境配慮の両立が求められている。本手法はCO2回収とバイオマス溶媒を用いて分析のグリーン化を実現し、日本企業のサステナビリティ報告や環境負荷低減に貢献しうる。
In the global GX context
The method aligns with global trends in green analytical chemistry and sustainability-driven quality control. While not directly about climate disclosure, it exemplifies how process improvements can reduce environmental footprint, relevant for life cycle assessment and Scope 3 reporting in chemical and cosmetics sectors.
👥 読者別の含意
🔬研究者:Presents a validated high-throughput SFC method that reduces solvent use and time, applicable to quality control of essential oils and other natural products.
🏢実務担当者:Analytical laboratories in cosmetics and fragrance can adopt this method for routine screening, reducing operational costs and environmental impact.
📄 Abstract（原文）
In recent years, the demand for greener analytical workflows has led to a renewed interest in supercritical fluid chromatography (SFC), which uses recycled carbon dioxide as the main mobile phase. In addition, the low viscosity of the supercritical CO 2 enables faster separations with a minimal consumption of organic solvents. A fast and high-throughput SFC method was developed in this work, for the screening of target oxygenated heterocyclic compounds (OHCs) in Citrus essential oils. These matrices are widely used in the formulation of fragrances and topical cosmetic products, and thus accurate and reliable methods are imperative for industries, given the phototoxic potential of some OHCs. A systematic investigation of stationary phases and co-solvents was carried out to assess the retention behaviour of the analytes as a function of key operational parameters (mobile phase modifier, flow rate, temperature, and pressure). Compared to conventional liquid-chromatography workflows, the SFC method resulted in a substantial decrease in analysis time (3.5 minutes per sample) and solvent usage (840 µL per run). Moreover, toxic solvents and additives were replaced with lower amounts of bio-based chemicals (6% of bio-methanol into CO 2 , isocratically). High-throughput capability (17 samples per hour) and minimal environmental impact render the method consistent with the overarching aims of green analytical chemistry, and suitable for sustainable routine quality control of essential oils. Quantitative analysis of target OHCs in bergamot, bitter orange, lemon, and grapefruit cold-pressed oils was performed, afterwards. The limits of detection and quantification were estimated in the 0.016-0.048 and 0.053-0.162 mg L -1 range, respectively.
🔗 Provenance — このレコードを発見したソース
- openalex https://doi.org/10.1016/j.greeac.2026.100366first seen 2026-06-20 05:19:46
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