Decarbonizing API Manufacturing: Conceptual Design and Scale-up Analysis of Continuous-Flow Electrosynthesis for Ibuprofen Production
API製造の脱炭素化：イブプロフェン製造のための連続フロー電解合成の概念設計とスケールアップ解析 (AI 翻訳)
Tuse Asrav, M. Alvarado-Morales, Gürkan Sin
🤖 gxceed AI 要約
日本語
本研究は、医薬品有効成分であるイブプロフェンの連続フロー電解合成法を提案し、実験室規模から工業規模へのスケールアップ解析を行った。銀カソードとイオン液体を用いた電気化学的カルボキシル化反応を基に、AVEVAプロセスシミュレーションを用いてプラント全体の設計と感度分析を実施。再生可能電力との直接結合により、従来のAPI製造プロセスに比べて大幅な脱炭素化が可能であることを示した。
English
This study proposes a continuous-flow electrosynthesis route for ibuprofen and performs conceptual design and scale-up analysis. Using a silver cathode and ionic liquid, the electrochemical carboxylation reaction is simulated in AVEVA Process Simulation with global sensitivity analysis. The results demonstrate technical viability and scalability, showing that coupling with renewable electricity can significantly decarbonize API manufacturing.
Unofficial AI-generated summary based on the public title and abstract. Not an official translation.
📝 gxceed 編集解説 — Why this matters
日本のGX文脈において
この研究は、製薬業界の脱炭素化に向けた電解合成技術の実用可能性を示しており、日本の製薬企業がScope1・2排出削減に活用できる可能性がある。ただし、イオン液体と銀電極の使用はコスト面での課題もある。
In the global GX context
This paper presents a scalable electrosynthesis route for pharmaceutical manufacturing, aligning with global efforts to decarbonize chemical production. It demonstrates a pathway to reduce Scope 1 and 2 emissions in the pharma sector, relevant for ISSB-aligned reporting and green chemistry initiatives.
👥 読者別の含意
🔬研究者:This paper provides a methodology for scaling up electrosynthesis from lab to industrial scale, useful for process intensification research.
🏢実務担当者:Pharma manufacturers can explore this electrochemical route as a potential low-carbon alternative for API production.
📄 Abstract（原文）
The decarbonization of pharmaceutical manufacturing is critical for achieving the industry’s net-zero targets, and electrochemistry is emerging as a promising green technology that could play a key role in this transition. This work evaluates a continuous-flow electrochemical route for ibuprofen synthesis through electrochemical carboxylation of 1-chloro-(4-isobutylphenyl) ethane as a low-carbon alternative that can be directly coupled with renewable electricity. Experimental studies have demonstrated the selective formation of ibuprofen using a silver cathode in the ionic liquid N-methyl-N-propylpiperidinium bis(trifluoromethanesulfonyl)imide (PP13 TFSI). While the reaction mechanism is based on laboratory-scale, batch experiments, this study develops a conceptual design and scale-up methodology for the continuous route to provide an evaluation of the industrial feasibility of this electrochemical pathway through a rigorous plant-wide simulation in AVEVA® Process Simulation. Global sensitivity analysis is employed to identify key operating variables and evaluate their impact on reactor and process performance, energy consumption, and ionic liquid recovery. These insights provide a robust foundation for informed decision-making in process intensification, demonstrating the technical viability and scalability of continuous flow electrosynthesis as a sustainable alternative to conventional API manufacturing.
🔗 Provenance — このレコードを発見したソース
- semanticscholar https://doi.org/10.69997/sct.137213first seen 2026-06-26 05:33:42
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