Recent Advances in Green Catalytic Multicomponent Reactions for Sustainable Synthesis

Unofficial AI-generated summary based on the public title and abstract. Not an official translation.

🔬研究者:Researchers in synthetic organic chemistry and green chemistry will find a consolidated overview of sustainable MCR strategies and directions for recyclable catalyst development.

🏢実務担当者:Chemical industry practitioners can identify greener alternatives for fine chemical synthesis, potentially reducing waste and energy costs.

Multicomponent reactions (MCRs) were useful synthetic tools in organic chemistry that allowed for the creation of complexity from easily accessible basic building blocks. Green MCRs provide effective and sustainable routes to the synthesis of chemical diversity when combined with catalytic processes. Recent developments in environmentally friendly multicomponent catalytic reactions based on energy‐saving techniques, renewable catalysts and green solvents are discussed in this study. These strategies, when coupled, improve not just the reaction's efficiency but also some of the green chemistry principles that reduce waste and energy consumption. Real‐world applications and challenges in the domain are examined using relevant examples, such as Biginelli, Ugi and Passerini reactions. Other future areas noted in the review include the development and application of recyclable catalysts in MCRs in the agricultural and pharmaceutical industries. Multicomponent reactions (MCRs) have revolutionized synthetic organic chemistry by allowing huge molecular frameworks to be efficiently constructed from simple, readily available starting components in a single operational step. When combined with catalytic approaches following green chemistry standards, MCRs provide a very sustainable and economical avenue to a wide range of chemical entities. This study reviews recent breakthroughs in multicomponent catalytic processes performed in ecologically friendly settings, with a focus on green solvents, renewable catalysts and energy‐efficient activation approaches. To maintain synthesis efficiency, selectivity, and scalability, the environmental impact is reduced to a minimal. These approaches, which vary from solvent‐free transformations under mechanochemical conditions to aqueous‐phase reactions with biocatalysts, are at the cutting edge of sustainable chemical synthesis. By combining green chemistry concepts into MCRs, synthetic operations are brought in line with worldwide sustainability goals while also improving atom economy and reducing hazardous waste. This paper gives prospective perspectives on the widespread use of green multicomponent reactions in academic and industrial settings, discusses the current state of the field and highlights key strategies.

• semanticscholar https://doi.org/10.1002/slct.202506024first seen 2026-06-10 05:31:30